Polymorphism of Interleukin-1β Gene and Susceptibility to Chronic Adenoiditis Development at Children of Siberia

The research objective was to establish a role of polymorphism of interleukin-1β gene in the locus 3954 (rs 1143634) on the chromosome 2q13-21 as a risk factor of an adverse course of the inflammatory process at chronic adenoiditis. The research is a part of the complex scientific subject “Translational Otorhinolaryngology” which was carried out in 2010-2012. The results of genotyping of 944 people were received. High total frequency of inheritance of mutant polymorphic allelic variants of interleukin-1β gene, including homozygous (C/C) and heterozygous (С/Т) carriage is revealed at children with chronic adenoiditis. The frequency was 95.5% in sampling. At a homozygous carriage of oligonucleotide replacement of thymine for cytosine in the position 3954 of interleukin-1β gene functional activity of interleukin-1β changedits pro-inflammatory effect increased by 100%. Children of this group had a heavy current chronic adenoiditis with the frequent aggravations, complications and the interfacing diseases at high concentration in blood serum interleukin-1β (298.4±8.2) pg/ml (control − 65.43 pg/ml) (p˂0.001). NATALIA TERSKOVA, NATALIA SHNAYDER, SERGEY VAKHRUSHEV